How you can Get ready for Entire Genome Sequencing


Genomics is a field of technology that changes at an alarmingly rapid rate. It’s difficult to find types of other fields that have undergone change at similar rates, but comparisons could include the evolution of computer technology in the last several decades or the rapid growth of Internet startups in the 90s. Unlike these examples, the growth of genome sequencing technology is limited by a certain technological sector, or at the very least, it’s been until now.

Sequencing technology is currently passing a crucial point, of which the cost of whole genome sequencing is in fact lower than the cost of running a conventional panel of genetic tests. Though it is difficult to calculate a precise figure with this, it probably is based on the range of $1K-$10K. Illumina’s HiSeq platform or IonTorrent’s Proton both promise genomic sequencing in this range, as well as Complete Genomics. Even as we pass this aspect, genome sequencing moves from the realm of research technology to viable clinical diagnostic test.

The consequences with this change may be observed in the growing widespread fascination with sequencing technology. Di truyền học  While technologies in this area have revolutionized many regions of research in the last decade, their used in clinical settings has profound implications with this industry. Research applications can only provide a restricted supply of profits. Getting into clinical applications provides access to a much bigger amount of capital, both because of the larger market and higher profit margins.

The clinical introduction of genome sequencing technology will change many aspects of healthcare in the next few years. Genome sequencing could eventually take the spot of a regular element of a patient’s healthcare record, in very similar way as blood type and allergies to medication are used today. However, we have plenty of ground to cover before we get to this point. For entrepreneurs in this field, this equates to a range of exciting opportunities.

While interpretation of genomic has been an essential area of research, the growing use of this data in clinical fields will generate a good demand for the unambiguous interpretation of results. Physicians want an unambiguous questions such as for instance disease predisposition, and they’d like a reputable party to assume the responsibility for making this judgement. Recently, an increasing number of companies have entered the area of genomic data interpretation, most of them small startups such as for instance Genformatic, a Bioinformatics company situated in Austin. Larger companies have also begun to target on providing these services. As this industry evolves, it is probable that more companies may enter this realm, and it is going to be interesting to observe how things develop in this area.

While a person with experience in Molecular Biology possesses the necessary skills to get ready and run libraries, plenty of things can make a mistake in this process. Even yet in pure research applications, sample preparation is an increasingly common service given by a number of centers, as well as boutique services, such as for instance Genome Organizer’s ChIP-Seq service. It’s not too researchers can’t perform these tasks, but when they’re available for a fee, they see little benefit to running these services for themselves. As genomic sequencing moves into the clinical realm, demand for such services can be anticipated to increase. There are very few hospitals with the existing capability to perform basic sample preparation, and this represents a new area of opportunity in this field.

Among the greatest regions of uncertainty in this area today is how samples will get from physicians’ offices to sequencing centers, and who will inform patients of their results. Though medical school curricula may 1 day include the interpretation of genomic data, we’re not even close to the period today. Currently, even the administration and interpretation of Genetic tests is generally left to individuals in the field of Genetic Counseling, in collaboration with statisticians and specialists. Though it is probable that a range of other professionals will take control the responsibility with this field as time goes on, it is probable that in the longer term, the growth can take place within this field.

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